Quatrième réunion annuelle du GDR Architecture et Dynamique du Noyau et des Génomes (ADN&G)

Session

Posters

Non programmé

salle de conférence "4R4 - Nicole Le Douarin" (CBI Toulouse)

19. Biophysical models of the Zfp608 locus in mouse cells

Marco Di Stefano (IGH)

Marco Di Stefano, Ivana Jerkovic, Giacomo Cavalli
Institute of Human Genetics, Université de Montpellier, CNRS, Laboratoire de Chromatine et Biologie Cellulaire, 34094 Montpellier, France

Chromosome structural organization contributes to fundamental processes in the cell nucleus, including DNA transcription, replication, and repair. Experimental and theoretical works unveiled that...

16. Chromosome elasticity with loop-extrusion activity

Dr hossein salari (Laboratory of Biology and Modelling of the Cell, Univ Lyon, ENS de Lyon)

The loop-extrusion process has emerged as a pivotal mechanism governing chromosome organization within the nucleus. However, the impact of this process on the effective stiffness of chromosomes remains largely unexplored. In this study, we introduce a novel polymer model to investigate the force-extension behavior of chromosomes with loop-extrusion activity. Our analytical and simulation...

13. How does the Ter linkage par3cipate in chromosome organiza3on and segrega3on in E. coli

Estelle Brendon (LMGM-CBI, Université Toulouse 3)

Coordina3ng chromosome segrega3on with cell division is a key-step of the cell cycle for any bacteria. E. coli does not seem to require an ac3ve system to segregate its chromosomes. Instead, entropy and a specific organiza3on of the chromosome into domains seem to explain the observed choreography. MatP is the DNA-binding protein responsible for organizing the ter region by preven3ng the SMC...

21. New insights into resistance to the metabolic inhibitor 2- deoxyglucose from studies in fission yeast

Adrien Birot (Université de Bordeaux et de Montpellier - CNRS)

The rewiring of glucose metabolism from mitochondrial respiration to
fermentation is a hallmark of cancer. This metabolic adaptation has been exploited in
ongoing therapeutic and diagnostic strategies. Notably, treating cancer cells with the
glucose analog 2-deoxy-D-glucose (2DG) reduces their proliferation presumably by
dampening the rate of glycolysis. However, this treatment leads to...

7. Polymer physics to investigate the elastic properties of bundled hydrogels : applications to collagen gels.

Erwan LE FLOCH (Université PAUL SABATIER)

Collagen gels are ubiquitous materials found in biological tissues, serving as structural support, regulating cellular processes, or contributing to wound healing.
Multiple models elucidate their tensile behavior through the lens of polymer physics [[1]][1].
Nevertheless, the characteristics of these gels under hydrodynamic pressure remain largely unexplored. Our recent findings...

15. The role of intrinsically disordered regions (IDR) of RNA polymerase I machinery in nucleolar organization and chromatin compaction of ribosomal DNA

Sarah DANCHE

In eukaryotes, the nucleolus is a specialized nuclear compartment where the early stages of ribosome biogenesis take place. The nucleolar organization and ribosomal DNA compaction reflect ribosome production from yeast to human.
In yeast, ribosomal DNA is a unique 1-2 Mb region of chromosome XII in which 100-200 copies of ribosomal DNA (rDNA) are repeated. Ribosome assembly is initiated by...