Orateur
Description
The loop-extrusion process has emerged as a pivotal mechanism governing chromosome organization within the nucleus. However, the impact of this process on the effective stiffness of chromosomes remains largely unexplored. In this study, we introduce a novel polymer model to investigate the force-extension behavior of chromosomes with loop-extrusion activity. Our analytical and simulation findings reveal that loop-extrusion activity enhances the effective stiffness of chromosomes in low-force regimes, while demonstrating reduced stiffness at higher force levels, consistent with experimental observations. Moreover, our simulations predict a hysteresis-like behavior in force-extension curves, indicative of memory retention within the loop-extrusion process.
