Orateur
Description
Accurate biological dose calculation in hadrontherapy remains a major challenge due to the complexity of inelastic processes governing energy deposition at the microscopic scale. My thesis project aims to improve biological dose modeling by establishing a direct link between ion-matter interactions and the predictions of the NanOx biophysical model. The work involves calculating ionization, excitation, and charge transfer cross sections of ions for biological targets, and assessing their impact on chemical yields and cell survival fractions. Correlations between these cross sections and nanodosimetric quantities are being investigated to identify the dominant mechanisms driving biological effects. These results are expected to provide insight into the role of fundamental interaction processes in biological damage. Based on this, a simplified version of NanOx will be developed, aiming to reduce computational cost and facilitate its integration into clinical treatment planning systems.