The main experimental challenging developments in positron emission tomography (PET) are currently focusing on improving the sensitivity either by pushing the time of flight (ToF) performances or extending the axial field of view. As an alternative the use of 3γ detection capability enables several extra advantages, including the possible enhancement of the ToF information to better locate the...
PET imaging is undergoing continuous improvements thanks to developments of new
detection approaches, new designs and new electronic chains. For example, whole-body
scanners' geometries, advances in detectors' time resolution, and improvements in TOF image reconstruction are hot topics for dynamic acquisitions.
Monte Carlo GATE simulations can be used to quantify the impact of these...
The correlation of molecular neuroimaging and behavior studies in the preclinical field is of major interestto unlock progress in the understanding of brain processes and assess the validity of preclinical studies in drug development. However, fully achieving such ambition requires being able to perform molecular images of awake and freely moving animals whereas currently, most of the...
As part of the european project RXNanoBRAIN, the image-guided radiation therapy and the radiosensitization by Gadolinium and Bismuth hybrid nanoparticles are investigated for the treatment planning of the glioblastoma brain tumor. In this context, we performed Gate Monte Carlo simulations to assess the deposited dose in clusters of Bismuth-Gadolinium nanoparticles in U251 glioblastoma cells....
In this study, we aimed to investigate the effect of flattened filter on dose distribution in a heterogeneous phantom using Monte Carlo simulation. The GATE Monte Carlo code was used to simulate photon beams of 6 MV in a heterogeneous phantom consisting of lung and breast tissues. The electrons accelerated by 6MV in flattened and unflattened modes were configured in Gaussian parameters. The...
Dose distribution is simulated by Monte Carlo (MC) method generally. However, due to its data dependency, complex model, long computational time, instead, our work utilize AI models to predict dose distribution in real time, which is a series of mathematical operations that fit on a wide range of data and flexible in handling new cases. Furthermore, this work compares the MC simulation...
The IDEAL project aims to substitute the patient specific quality assurance (PSQA) measurements for light ion beam therapy by independent dose calculation (IDC) using Gate-RTion. In this contribution, the commissioning status of the IDEAL v1 at MedAustron Ion Therapy center will be discussed including a physics settings variation study. Further, the status of the integration of IDEAL v1 into...
In Proton Therapy Center in Prague we have developed a method for patient based quality assurance. Our project is based on Monte Carlo (MC) and is built on Gate. By means of MC, dose computational algorithms of local treatment planning systems XiO 5.1 (Elekta, Sweden) and RayStation 11B (RaySearch, Sweden) can be verified as MC method provides the highest calculation accuracy. It provides...
The PETITION PET detector, has been developed for in-beam use at Gantry 2 at PSI,
with an open ring design allowing for measurement of patient activation both during and
following proton therapy treatment. Tools for time resolved simulations of patient
treatments have been implemented using Gate. Intra-field imaging in the dead time
between delivery of each energy layer, approximately 100...
In ion beam therapy, Monte Carlo (MC) particle transport simulations are being increasingly used to perform independent dose calculation (IDC) for quality assurance in light ion beam therapy. In practice, IDC consists in recomputing the dose in the patient starting from the treatment plan specifications, with a Monte-Carlo engine. The results can be compared with the planned dose as a...
Monte Carlo (MC) simulations of microdosimetric spectra are available for different codes, detectors and particle types/energies. While good results can be achieved if the detector geometry is modelled in detail [1, 2], a simpler approach can also result in very good agreement.
At five positions along a 238.6 MeV/u carbon ion pencil beam, spectra were collected using the Silicon MicroPlus...
