8-12 July 2019
Cité des Congrès
Europe/Paris timezone

Helical Superstructure of Intermediate Filaments

9 Jul 2019, 10:00
30m
Salle J (Cité des Congrès)

Salle J

Cité des Congrès

Speaker

Prof. Hervé Mohrbach (Université de Lorraine)

Description

Intermediate filaments are the least explored among the large cytoskeletal elements. We show here that they display conformational anomalies in narrow microfluidic channels. Their unusual behavior can be understood as the consequence of a previously undetected, large-scale helically curved superstructure. Confinement in a channel orders the otherwise soft, strongly fluctuating helical filaments and enhances their structural correlations, giving rise to experimentally detectable, strongly oscillating tangent correlation functions. We propose an explanation for the detected intrinsic curving phenomenon — an elastic shape instability that we call autocoiling. The mechanism involves self-induced filament buckling via a surface stress located at the outside of the cross section. The results agree with ultrastructural findings and rationalize for the commonly observed looped intermediate filament shapes. Beyond curvature, explaining the molecular origin of the detected helical torsion remains an interesting challenge.

Ref: L.Bouzar, M.M.Müller, R.Messina, B.Nöding, S.Köster, H.Mohrbach, I.M.Kulić, Phys. Rev. Lett, 122, 098101 (2019).

Choix de session parallèle 2.4 Fluctuation et biologie

Primary author

Prof. Hervé Mohrbach (Université de Lorraine)

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