Apr 10 – 11, 2014
Université Pierre et Marie Curie (UPMC)
Europe/Paris timezone

Gene expression as a function of genome position, implications on growth rate and growth phase dependence of nucleoid organization.

Apr 10, 2014, 3:55 PM
25m
Tour 22, Couloir 22-23, 4e étage, Salle de Conférence de l'IMPMC (Université Pierre et Marie Curie (UPMC))

Tour 22, Couloir 22-23, 4e étage, Salle de Conférence de l'IMPMC

Université Pierre et Marie Curie (UPMC)

Paris, FRANCE

Speaker

Dr Bianca Sclavi (LBPA, UMR 8113)

Description

The bacterial genome is not uniformly organized, with binding sites for nucleoid associated proteins and topoisomerases found in clusters or in a gradient from the origin to the terminus, in addition the position of several key genes regulating cellular growth and adaptation is conserved when comparing the known gamma proteobacterial genomes. We thus asked whether the position of a gene can influece its expression and its regulation in response to stress. We have used a fluorescent protein reporter construct at six different positions along the chromosome in order to address this question.

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