Orateur
Description
In nature, molecular ions with the same mass and charge can exist with various structures. These isomers exhibit different physical or chemical properties. For a better understanding of light-induced processes on molecules, one of the actual challenges is to couple structural analysis of molecular ions with light matter interaction studies. To probe the structure of gas-phase molecular ions, especially for complex and flexible systems, ion mobility spectrometry (IMS) combined with mass spectrometry (MS) and infrared multiple photon dissociation (IRMPD) provides a powerful approach [1,2].
In the DYNAMO group, molecular ions in the gas phase are studied with interests in both fundamental and application aspects by using state of the art table-top light sources technologies (from mid-infrared to extreme ultraviolet) coupled to electrospray Ionization source (ESI) and mass spectrometers. A novel IMS experimental apparatus using ultrahigh-resolution traveling-wave SLIM (Structures for lossless ion manipulation) technology [3] is currently under construction. This IMS system will be coupled to an ESI-MS-IRMPD experimental setup for the analysis of carbohydrates and complex molecular assemblies.
In ESI-SLIM-MS-IRMPD experiments, molecular ions are generated by ESI and separated based on their structures using the SLIM device. Selected isomers are then trapped, mass-isolated, and irradiated with a tunable IR laser to obtain IRMPD spectra, which provide structural fingerprints of the selected ions (Figure 1).
The ESI-IMS device with preliminary results will be presented.
References
[1] Schindler, B et al. FAIMS-MS-IR spectroscopy workflow: a multidimensional platform for the analysis of molecular isoforms. Int. J. Ion Mobil. Spec. 20, 119–124 (2017).
[2] Ben Faleh, A et al. Combining ultrahigh-resolution ion-mobility spectrometry with cryogenic infrared spectroscopy for the analysis of glycan mixtures. Anal. Chem. 91, 4876–4882 (2019)
[3] Ibrahim, YM et al. New frontiers for mass spectrometry based upon structures for lossless ion manipulations. Analyst 142, 1010-1021 (2017)
| Do you submit an abstract for a talk or a poster? | poster |
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| If your abstract isn’t selected for a plenary talk, would you like to present it as a poster? | Yes |