Cinquième réunion annuelle du GDR Architecture et Dynamique du Noyau et des Génomes (ADN&G)

Cohesion vs loop extrusion: modeling the dual role of cohesins in budding yeast

Non programmé

20m

amphithéâtre (GENOPOLYS)

Orateur

Dr Daniel Jost (Laboratoire de Biologie et Modélisation de la Cellule, ENS Lyon)

Description

In budding yeast, cohesins are central to maintain sister
chromatids cohesion and to shape the mitotic chromosomes. Here I'll
present our effort to model the interplay between cohesin-mediated
cohesion and loop extrusion and investigate how it shapes the
organization of mitotic chromosomes in yeast. By comparing model
predictions and Hi-C experimental data, we observe the signature of
asymetric cohesion and a stochastic loop extrusion.