The bacterial DNA segregation is prevalently performed through the ParABS system for most chromosome and low-copy number plasmids. It consists in two proteins: (i) ParB a DNA binding protein with a specific binding site at parS. It has been recently found to be a CTP-ase; (ii) ParA, an ATP-ase whose ATP hydrolysis is catalyzed by ParB and (iii) parS, a centromere-like sequence where ParB can...
Although our understanding of the involvement of heterochromatin architectural factors in
shaping nuclear organization is improving, there is still ongoing debate regarding the role of
active genes in this process. In this study, we utilize publicly-available Micro-C data from mouse
embryonic stem cells to investigate the relationship between gene transcription and 3D gene
folding. Our...
Chromosomal structural organization contributes to fundamental processes in the cell nucleus, including DNA transcription, replication, and repair. Experimental and theoretical works unveiled that chromosome organization consists of a complex aggregate of layers: entire chromosomes occupy distinct regions of the nucleus, called territories; below, at the tens of Mega-bases (Mb) scale, active...
