Orateur
Description
"Microbeam radiation therapy (MRT) is a treatment modality based on spatial fractionation of synchrotron generated x-rays into parallel, high dose, microbeams of a few microns width. MRT leads to high dose gradients replicated at a micrometric scale inside the irradiation field to induce the dose-volume effect. Promising preclinical results of MRT on brain tumors and epilepsy encourage its clinical transfer.
The present work reports advances toward a safe clinical transfer of MRT. For clinical transfer of MRT, its underlying radiobiological mechanisms must be known. The efficiency and the risks of treatment should also be evaluated. Having a high gradient micrometric dose distribution, it is necessary to provide a precise calculated dose map in micrometric scale. For this reason a multi-scale full Monte-Carlo dose calculation engine called penMRT has been developed and cross validated to other calculation methods. PenMRT takes into account the voxelized geometry of the patients (CT-scans) and offers an adaptive micrometric dose calculation grid independent to the CT size. Using penMRT, high resolution differential dose-volume histograms can be extracted and correlated to biological data.
In the future, penMRT will be included in a commercial treatment planning system as the calculation core. PenMRT is a versatile calculation engine thanks to its multiscale approach. This calculation engine can also be used beyond the MRT platform, whenever high resolution calculated doses with precision is mandatory (e.g, stereotactic radiosurgery or dose distribution in presence of nanoparticles)."
