Neutrino astronomy is the advanced frontier of astroparticle physics. It has opened a new window on high energy events in the Universe and has the ambition to shed light on still unknown processes pertaining to the production and the acceleration of ultra high energy cosmic rays. Tiny cross section and low expected fluxes of cosmic neutrinos require huge size neutrino detectors, at least km3-scale. This goal is reachable using large amount of natural deposit of water, under sea, lakes or ice.
This talk describes the status of neutrino telescopes in the Mediterranean Sea, in particular of the KM3NeT research infrastructure currently under construction in two sites, off-shore the southern French coast and off-shore the Sicily coast, respectively. First results and future perspectives are discussed with special attention to a multi messenger approach.