Sixième réunion du GdR Architecture et Dynamique Nucléaire (ADN)

How pinching a DNA plectoneme facilitates the interaction between distant genes

Non programmé

15m

Orateur

Prof. Nicolas Destainville (Univ. Toulouse III-Paul Sabatier)

Description

Normally separated by a distance on the order of 10 nm, the two opposite double-strands of a DNA plectoneme must be brought closer if a protein implicated in genetic regulation is to be bound simultaneously to both strands. We propose an analytic calculation of the energetic barrier, of elastic nature, required to bring closer two loci situated on the two double-strands. We also examine how this energy barrier depends on the DNA supercoiling.