28 janvier 2016
Institut Jacques Monod
Fuseau horaire Europe/Paris

Polymer model of supercoiled molecules including multiple structural forms of DNA

Non programmé
15m
Salle François Jacob (Institut Jacques Monod)

Salle François Jacob

Institut Jacques Monod

15 Rue Hélène Brion 75013 Paris

Orateur

Dr Thibaut Lepage (TIMC-IMAG, Université Joseph Fourier, CNRS UMR 5525, Grenoble)

Description

DNA supercoiling lies at the core of transcriptional regulation. Except for a few cases, capturing its impact in vivo remains elusive, though. Supercoiling is indeed distributed in a non-trivial way between twist, writhe (plectonemes) and change of structural forms of DNA (including denaturation) and depends, a priori, on genomic sequences. In this talk, we will present a polymer model of DNA that allows studying these properties quantitatively. We will show in particular the possibility to study the behavior of DNA sequences whose length corresponds typically to the topological microdomains that have been experimentally highlighted in *Escherichia coli* and *Salmonella typhimurium*.

Auteurs principaux

M. Ivan Junier (TIMC-IMAG, Université Joseph Fourier, CNRS UMR 5525, Grenoble) Dr Thibaut Lepage (TIMC-IMAG, Université Joseph Fourier, CNRS UMR 5525, Grenoble)

Documents de présentation

Aucun document.