Since about the year 2000, when PET/CT, the medical imaging device combining Positron Emission Tomography (PET) and X-ray Computed Tomography (CT), was first introduced, hybrid imaging devices are the modality of choice in clinical and research environments. Mainly oncological studies, i.e. search of primary tumors or metastasis, heavily benefit from the fact, that abnormal and mostly focal radioactive tracer uptake are detected by PET and correlated to the anatomical site by means of CT. Hybrid imaging devices are made to be complementary, adding information, which otherwise would not be available. It was the success of PET/CT, that has spurred new projects attempting to combined PET and Magnetic Resonance Imaging (MRI) into a single device. In contrast to PET/CT, where patient studies are performed in a sequential manner, starting with CT, followed by PET, data acquisition with MR/PET provide the option of real simultaneous studies. The fact, that MR/PET seems possible now, results from recent advances in detector developments, namely operating a large number of Avalanche Photo Diodes inside a strong magnetic field. PET detectors benefit from such developments opening a new regime of hybrid medical imaging.
Does it mean, that image registration is completely solved with hybrid imaging or are there obstacles yet to be solved? And what about imaging with animals? Is hybrid imaging with small animals feasible and also with MR/PET?
Still a lot of problems waiting to be solved!!