Cancer radiotherapy is a locoregional treatment of cancer using physical processes. Its place has continued to be consolidated for more than a century with very rapid technological developments in recent years driven by the evolution of the possibilities of medical imaging and faster and more accurate dose calculations. It has continuously developed in close association with surgery and...
These lectures will cover an ntroduction to the physical and radiobiological characteristics of the different approaches and technological issues associated with their development.
The approach in developing new radiotherapy (RT) approaches is to succeed in increasing the therapeutic window for different types of cancer, either by sparing healthy tissues, or by being more effective on the...
The DNA centered view of radiobiology was comforted in the last century by the finding that the level of unrepaired DNA lesions can be correlated with the cell sensitivity to radiation. This drove efforts to improve tumor cell killing, by focusing on enhancing tumors radiation dose and producing deleterious DNA damage. However, events occurring in the cytoplasm or at the cell membrane also...
Accélérateurs pour la radiothérapie et l’hadronthérapie, systèmes de délivrance isocentriques, accélérateurs pour la BNCT et la production de radioisotopes, contraintes cliniques
These lectures will cover an ntroduction to the physical and radiobiological characteristics of the different approaches and technological issues associated with their development.
The approach in developing new radiotherapy (RT) approaches is to succeed in increasing the therapeutic window for different types of cancer, either by sparing healthy tissues, or by being more effective on the...
Medical imaging: from physical measurement to clinical diagnosis
In this course, we will review the principle and evolution of anatomical, functional and molecular imaging modalities used in clinical research. After recalling the major dates in the history of medical imaging, the various techniques will be described in terms of their physical principles of detection and the clinical...
The DNA centered view of radiobiology was comforted in the last century by the finding that the level of unrepaired DNA lesions can be correlated with the cell sensitivity to radiation. This drove efforts to improve tumor cell killing, by focusing on enhancing tumors radiation dose and producing deleterious DNA damage. However, events occurring in the cytoplasm or at the cell membrane also...
Since the middle of the last century nuclear detectors have been used in medical application as well for diagnostic or treatment, especially in cancer patient course.
Beside the conventional X-rays imaging for diagnostic, scintillators are used for single photon (SPECT: Single-Photon Emission Computed Tomography) or double photon (PET: Positron Emission Tomograpghy) 3D image reconstruction....
Medical imaging: from physical measurement to clinical diagnosis
In this course, we will review the principle and evolution of anatomical, functional and molecular imaging modalities used in clinical research. After recalling the major dates in the history of medical imaging, the various techniques will be described in terms of their physical principles of detection and the clinical...
Pour une imagerie et des traitements combinés (approche théranostique), vers une médecine personnalisée. Enjeux de production quantitative et qualitative
Since the middle of the last century nuclear detectors have been used in medical application as well for diagnostic or treatment, especially in cancer patient course.
Beside the conventional X-rays imaging for diagnostic, scintillators are used for single photon (SPECT: Single-Photon Emission Computed Tomography) or double photon (PET: Positron Emission Tomograpghy) 3D image reconstruction....
Accélérateurs pour la radiothérapie et l’hadronthérapie, systèmes de délivrance isocentriques, accélérateurs pour la BNCT et la production de radioisotopes, contraintes cliniques
Pour une imagerie et des traitements combinés (approche théranostique), vers une médecine personnalisée. Enjeux de production quantitative et qualitative
Radiotherapy uses ionising radiation to damage the DNA of tumour cells. According to international recommendations (ICRU), the doses delivered during treatment must not deviate by -5%/+7% from the doses prescribed by the radiation oncologist in order to maximize local control and limit complications. To achieve this, it is necessary to describe the properties of the radiation beams precisely....
Iterative PET Image Reconstruction, from Convex Optimization to Deep Learning
In this course we will review the principles of tomographic image reconstruction with a focus on Positron Emission Tomography (PET). We will first present the context of nuclear medical imaging, review the basics of ill-posed tomographic inverse problems before introducing the specificities of iterative PET image...
Plateforme GATE en imagerie et en radiothérapie (Travaux pratiques prolongeant le cours, sur un serveur déporté)
Radiotherapy uses ionising radiation to damage the DNA of tumour cells. According to international recommendations (ICRU), the doses delivered during treatment must not deviate by -5%/+7% from the doses prescribed by the radiation oncologist in order to maximize local control and limit complications. To achieve this, it is necessary to describe the properties of the radiation beams precisely....
Electrons and light ions have been accelerated following the interaction of
an intense laser pulse with a plasma for about 30 years. Nowadays, Laser
Plasma Accelerators (LPA) are versatile sources capable of producing energetic
electron and ion bunches with remarkable propreties. LPA benefited from
the constantly increasing repetition rates of high intensity lasers that increased
from a...
Iterative PET Image Reconstruction, from Convex Optimization to Deep Learning
In this course we will review the principles of tomographic image reconstruction with a focus on Positron Emission Tomography (PET). We will first present the context of nuclear medical imaging, review the basics of ill-posed tomographic inverse problems before introducing the specificities of iterative PET image...
