Présidents de session
Applications and Interdisciplinary physics
- isabelle monnet (CIMAP)
Applications and Interdisciplinary physics
- Jimmy Rangama (CIMAP)
Applications and Interdisciplinary physics
- Anne-Marie Frelin (GANIL, CEA/DSM-CNRS/IN2P3, Caen, France.)
The fabrication of nanoporous PAA-g-PVDF membranes is based on the selective chemical etching of Swift Heavy Ions (SHI) tracks in a polymer thin film followed by AA radiografting inside the etched ion-tracks. PAA functionalized nanopores have demonstrated to efficiently trap and preconcentrate metal ions presents in water at open circuit. This passive metal adsorption at solid-liquid interface...
The study of ion collision with biologically relevant molecules in the gas phase has received increasing interest in recent years in parallel with the development of ion beam therapy. Indeed, these studies help understanding the fundamental mechanisms involved at the molecular level such as fragmentation and electron emission. To study such processes, we have recently built an experimental...
Nuclear materials define a class of solid of interest for the nuclear industry with the specificity of being submitted to intense irradiation fields. Nuclear fuels and transmutation matrices deserve special attention due to their location at the core of the reactor, and due to the complexity of irradiation sources to which they are subjected, leading to both physical (radiation damage, atomic...
DNA origami nanostructures represent a unique substrate for in singulo experiments with biomolecules, nanotechnology and medicine. In our recent experiments at GANIL, we used these nanostructures as nano-dosimeters to observe damage to DNA. Patterning of the surface deposited DNA origami as well as damage to nanostructures placed in bulk water will be described with focus on physico-chemical...
New accelerators are being developed, either for medical applications (X-ray radiotherapy, hadrontherapy, radiotherapy by synchrotron radiation and "flash" therapies), or for nuclear physics. These developments create the need for very precise beam monitoring with fast counting in a highly radiative environment. An important issue is the adaptation to the temporal beam structures, which vary...
Glioblastoma (GBM) are brain tumors resistant to conventional therapies, in particular to radiotherapy based on X-rays. Therefore, the use of hadrontherapy appears as very appealing strategy thanks to their finite dose deposition to spare normal brain tissue but also to their greater biological efficacy toward radioresistant tumor cells and their low sensitivity to hypoxia, a well know factor...
For several years, many radionuclides (RN) are routinely used in nuclear medicine either for imaging ($\gamma$ and $\beta^+$ or positron) or for therapy ($\alpha$, $\beta^–$, Auger electron emitters). They are most-often administered in the form of a radiopharmaceutical, composed of the selected RN and a targeting unit (nanoparticles or biological vectors, like peptides or antibodies)...
The REPARE ANR project aims at developping a high power targetry to optimize the production of the promising alpha emitter $^{211}$At in the $^{4}$He($^{209}$Bi,2n)$^{211}$At fusion-evaporation reaction. For this, a first task is the precise measurements of several cross-sections to control the production of potential contaminants and to optimize the synthesis of $^{211}$At. Several...
Targeted Alpha Therapy (TAT) offers a promising approach to treat cancer, particularly micrometastases, by utilizing the short range of alpha particles and their high linear energy transfer. Astatine-211, which belongs to the halogen family also shares chemical properties with Iodine, a radioisotope commonly used for imaging and also widely used to treat thyroid cancer. This similarity enables...
