Orateur
Description
The PICTURE project aims at improving the biological dose prediction of innovative targeted radioelement-based therapies involving low-energy ions (such as BNCT or alpha targeted radiotherapy), using adapted simulation codes and the biophysical model NanOx.
The experimental part of the project has the objective of characterizing the biological effect of cancerous mammalian cells in different ion irradiation conditions in order to furnish biological data to parametrize the prediction models. The ALTO platform allows to irradiate samples with a large number of ion types in the energy range of our interest. However, ALTO is currently dedicated to nuclear physic experiments and it is therefore necessary to install a beamline capable of hosting irradiation experiments with living biological samples. The Radiograaff beamline consists of a double scattering foil and collimation system, used to produce an homogenous beam at the sample position. This line is currently being adapted on the ALTO platform and optimized to fulfill the irradiation quality requirements for radiobiological irradiations.
In this presentation, the latest advances on this numerical optimization study and implementation process will be presented.
