A.M. Frelin1, G. de France1, A. Doudard1 and X. Ledoux1
1 Grand Accélérateur National d’Ions Lourds (GANIL), CEA/DRF CNRS/IN2P3, 14076 Caen, France.
La mise en service de l’installation SPIRAL 2 au GANIL ainsi que la diversité des domaines scientifiques présents sur le plateau Caennais constituent un environnement idéal pour le développement et l’étude des applications de la physique...
Les outils de contrôle du faisceau utilisés dans l'irradiation conventionnelle peuvent ne pas convenir dans le cas d'une irradiation utilisant un débit de dose ultra-élevé > 40 Gy/sec (conditions FLASH). Pour surveiller le faisceau, un détecteur rapide couplé à une gamme dynamique élevée est nécessaire. Un tube photomultiplicateur mesurant la fluorescence de l'azote produite par l'interaction...
DOSIFLASH est un moniteur développé pour la machine ElectronFlash situé à l'institut Curie.
Ce système est composé d’un Beam Current Transformer (BCT) qui mesure le profil du courant faisceau sur une plage de 1µA à 140 mA avec une correction du Droop Rate inférieure à 0,2 %/µs. Une comparaison de la mesure faite par le BCT avec les toroïdes la machine montre la proportionnalité des deux...
Le contrôle en ligne du parcours des ions dans le patient en hadronthérapie représente un challenge, sa résolution permettra de réduire les marges autour du « Clinical Target Volume » (CTV) ainsi que le nombre de champs d’irradiation nécessaires. Ce contrôle est basé sur la détection de particules secondaires, notamment les gamma prompts qui présentent un profil d’émission corrélé à ce...
We are conceiving a new imaging modality called Prompt Gamma Time Imaging (PGTI) to achieve the real time measurement of the proton range during particle therapy treatments. The goal of PGTI is to reconstruct an image of the vertex distribution of Prompt Gamma rays (PG) emitted from the patient, through the exclusive measurement of particle Time-Of-Flight (TOF). The start trigger is given by a...
Four new microdosimetry systems based in multi-arrays of 3D silicon detectors and covering distances of several centimeters have been developed, characterized, and tested. The devices are based on individual detectors having a cylindrical shape and a size comparable to that of human cells (20 µm-thick, 25 µm-diameter). The four systems consist of different configurations and geometries of...
The PICTURE project aims at improving the biological dose prediction of innovative targeted radioelement-based therapies involving low-energy ions (such as BNCT or alpha targeted radiotherapy), using adapted simulation codes and the biophysical model NanOx.
The experimental part of the project has the objective of characterizing the biological effect of cancerous mammalian cells in different...
In the past years, advanced techniques were developed for particle therapy to deliver a more conformal dose to the tumor while spearing healthy tissues. However, the treatment of moving tumors with ion beams is still challenging. In the case of lung cancer, the respiratory motion of the patient can induce strong doses inhomogeneities and range shifts during the treatment due to high density...
Short-lived radioisotopes of the terbium family show great prospects in theranostics nuclear medicine, especially 155Tb which can be used for single-photon emission tomography (SPECT) and for Auger therapy. Nevertheless, 155Tb is mainly produced by spallation nuclear reactions; insufficient production and high cost have limited its application. An alternative way to increase their availability...
Biophysical models are of interest to estimate the biological dose in radiation therapy. The main output of these models are the alpha and beta coefficients describing cell survival as a function of dose. Such information may be used for instance to optimize beam parameters in hadrontherapy when integrated into treatment planning systems. However, novel radiation therapy modalities such as...
Auteurs: Pierre Beaudier1, Laurent Plawinski1, Guillaume Devès1, Philippe Barberet1, Denis Dupuy2, Hervé Seznec 1
1Laboratoire de Physique des 2 infinis Bordeaux (LP2iB), Université de Bordeaux.
2Laboratoire ARNA (Acides nucléiques : Régulations naturelles et artificielles), INSERM
Email: beaudier@lp2ib.in2p3.fr
L’objectif des études de dommages liés aux rayonnements ionisants (RI) a...
In this work the formation of hydrogen peroxide (H2O2) is measured after irradiation of ultrapure water with the ARRONAX proton beam under Ultra-High-Dose-Rate (UHDR) conditions and compared to conventional mode. A FLASH Effect was observed under Air in UHDR conditions attributed to the reaction of aqueous electrons e-aq with the precursors of H2O2 formation. In order to investigate this...
The goal of the FLASHMOD project is to develop an end-to-end environment for a proton beam in VHDR conditions at ARRONAX facility.
In this work we present our Geant4-DNA Monte Carlo simulation results.
A beta version of Geant4-DNA (under development) has been tested to model water radiolysis species at different dose rates with and without scavengers (N2O and Argon).
Obtained G-values for...
Auteurs: Eloïse Salles², Yasmine Ali1, Caterina Monini1, Etienne Russeil², Jean Michel Létang3, Etienne Testa1, Lydia Maigne² et Michel Beuve3
1 Université de Lyon 1, CNRS/IN2P3, Institut de Physique des deux Infinis de Lyon, 4 avenue Enrico Fermi 69100 Villeurbanne cedex France
² Université Clermont Auvergne, CNRS/IN2P3, Laboratoire de Physique de Clermont, 4 avenue Blaise Pascal 63178...
Auteurs: T. Tabanou1, C. Massard1, J-L. Piro 2, M. Lefebvre1, G. Rivrais1, P. Vernet1 et I. Balandier1
1Université Clermont Auvergne, CNRS, LPC, F-63000 Clermont–Ferrand, France
2Université Clermont Auvergne, CNRS, IRD, LMV, F-63000 Clermont–Ferrand, France
(Résumé entier à venir)
"Development of Enriched Gadolinium Target for Cross Section Measurement and Future Production of Terbium "
Short-lived radioisotopes of the terbium family show great prospects in theranostics nuclear medicine, especially 155Tb which can be used for single-photon emission tomography (SPECT) and for Auger therapy. Nevertheless, 155Tb is mainly produced by spallation nuclear reactions;...
