Orateur
Description
Chromatin is partitioned into subcompartments that differ from each other with respect to their compaction, molecular composition and biological function. One example are the micron-sized spherical heterochromatin foci that are present in several differentiated cell types. It has recently been proposed that phase separation is the driver of this type of chromatin organization. I will briefly introduce the different flavors of phase separation that might be at play, along with the strategies to detect them. I will then compare the different models to our recent experiments on DNA-based condensates in the test tube and on heterochromatin foci in living cells, and to our in silico analysis of cellular stoichiometries.
see also the two companion posters:
Cheryn ALI : What the composition of condensates teaches us about phase separation
Dominika LEWANDOWSKA : Visualizing heterochromatin formation on the single-molecule level
