Orateur
Description
Interphase chromosomes hierarchically organized into topologically-associated domains (TADs) at few kilo-basepair scales and compartments at mega-basepair scales. Recent studies suggest that the structural properties of chromosomes may alter local chromosome dynamics. Using heteropolymer model and Monte-Carlo simulations, we provide a comprehensive study of chromosome dynamics. We show that local heterogeneous dynamics emerge from TADs and compartments. Our analysis reveals that strong intra-TAD encounters lead to three-dimensional (3D) condense regions and eventually coherent motions and anomalous diffusions. We show that our model is able to qualitatively predict the heterogenous dynamics of chromosome loci inside the nucleus as well as the local anomalous diffusions, reported by live tracking single-locus experiments.
