Orateur
Dr
marcelo nollmann
(CNRS)
Description
DNA is organized at multiple length scales, from nucleosomes to chromosome territories. However, it is at intermediate levels of organizations that tissue-specific transcriptional regulation takes place. We will investigate this regulation during the early stages of differentiation in Drosophila embryonic development. For this, we have developed new imaging methods that rely on the use of micro-fluidics to perform sequential and combinatorial acquisition of tens of different species in single cells. These techniques revealed the existence of activating or repressing enhancer hubs that provide a scaffolding for the regulation of transcription during early embryogenesis.
Auteur principal
Dr
marcelo nollmann
(CNRS)
