Dr
Pierre-Etienne Meunier
(laboratoire d’informatique fondamentale de Marseille (LIF), UMR 7279, CNRS- Université Aix-Marseille, France)
Self-assembly is the process by which unorganized atomic components coalesce into complex shapes and structures. Its study started at the end of the 90s, from the point of view of computer scientists. Since then, it has yielded both an accurate theory of how things form at the nanoscale, and an impressive number of practical implementations at the nanoscale, in particular using DNA: fractal...
Prof.
KeQin Zhang
(National Engineering Laboratory for Modern Silk, College of Textile and Clothing Engineering, Soochow University, Suzhou, China, 215123)
Besides Science: there is rock climbing
Prof.
David J. Wales
(Cambridge University, Department of Chemistry)
Coarse-graining the potential energy surface into the basins of attraction of local minima provides a computational framework for investigating structure, dynamics and thermodynamics in molecular science. Steps between local minima form the basis for global optimisation via basin-hopping and for calculating thermodynamic properties using the superposition approach and basin-sampling. To treat...
Prof.
Laurent Vuillon
(Laboratoire de mathématiques du Bourget du lac (LAMA), Université de Savoie, France)
Protein oligomers are made by the association of protein chains via intermolecular amino acid interactions (interaction between subunits) forming so called protein interfaces. This talk proposes mathematical concepts to investigate the shape constraints on the protein interfaces in order to promote oligomerization. First, we focus on tiling the plane (2 dimensions) by translation with abstract...
Prof.
Sylvain Séné
(Laboratoire d'informatique fondamentale, université Marseille, France)
In this talk will be presented fundamental results which show formally that the environment of interaction networks plays a central role on their dynamical behaviours. Although an application to a biological network will be discussed, the focus will notably put on probabilistic cellular automata.
Dr
Claire Lesieur
(AGIM (Aging and Imaging), UGA-CNRS, Grenoble)
Proteins are biological entities made of a chain of amino acids bound to one another in a specific sequence. Based on the sequence and the environment, the protein acquires a tridimensional shape called tertiary structure (3D-structure) suitable for its biological function. The vast majority of proteins are oligomers which assemble several copies of their chains in order to function. They...
Prof.
Ke-Qin Zhang
(National Engineering Laboratory for Modern Silk, College of Textile and Clothing Engineering, Soochow University, Suzhou, China, 215123)
Nature produced a wide variety of materials with an extensive array of interesting structures which have been explored and adapted for human use. One of the best natural materials is silk, which has been used since ancient times. As a functional fiber, silk features exceptional mechanical properties such as high tensile strength and great extensibility, making it one of the toughest materials...
Prof.
Sylvie Ricard-Blum
(Team Extracellular interaction Network, UMR 5086 CNRS - University Lyon 1, France)
Twenty-eight collagen types have been identified so far in mammals and all of them contain a triple-helical domain, which is a characteristic feature of the collagen superfamily. The triple-helical domains of collagens are comprised of three polypeptide chains, called chains, which adopt a left-handed polyproline II helix conformation. These chains are predicted to be intrinsically...
Prof.
Dan S. Tawfik
(Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, 76100, Israel)
Over 60% of the known folds carry out one or two enzymatic functions, while few folds, e.g. the TIM-barrel and Rossmann folds, exhibit hundreds. Are there structural features that make a fold amenable to functional innovation (innovability)? Do these features relate to robustness – the ability to readily accumulate sequence changes? I will discuss several hypotheses regarding the relationship...
Prof.
Kave Salamatian
(LISTIC, Université de Savoie, Annecy-le Vieux, France)
A major characteristic in biology is resilience. We witness in permanence resilience in form of redundancy in biological systems, the human has two kidneys, for example. At the same time biological system are very efficient and do not waste resources. The aim of this talk will be investigate resilience from a system theory and information theory view point and to introduce concepts of...
