Orateur
Prof.
Christine Nazaret
(IMB, Universite Bordeaux 1)
Description
Developing dynamic models of metabolic pathways of the whole mitochondria could help in predictive or preventive medecine. But theses pathways are necessarily large and complex with lots of variables that can not be measured directly in vivo currently. Besides the different existing rates that describe the kinetic behavior of enzymes in this network are mostly non linear (in terms of parameters and variables) which leads to difficulties in adjusting the parameters.
That is why searching for a simple rate that describe the kinetic behavior of enzymes is useful. In this context, we derive an equation, called EMA (Extended Mass Action)
Next we studied our abilities to adjust the parameters of this new equation theoretically and numerically.
Finally we apply it to our experimental data derived from complex 1 enzymatic reaction.